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Principles of Protein–Protein Association

Professor Harold P Erickson


Protein–protein associations are fundamental to biological mechanisms. Developed from lectures given to beginning graduate students in cell and molecular biology, this book presents general principles of thermodynamics and kinetics, and structural principles of protein–protein interface as well as guided reading of informative classic papers. Faculties organizing similar classes, and students and researchers wishing to learn on their own, will also find this book of use.

About Editors

Harold P Erickson is a professor in the Departments of Cell Biology, Biochemistry and Biomedical Engineering at Duke University. Having received his PhD in biophysics from Johns Hopkins University in 1968, he did postdoctoral work with Aaron Klug at the MRC lab in Cambridge, England, developing techniques for computer reconstruction of electron microscope images. His research career at Duke University has focused the cytoskeleton and extracellular matrix, with an emphasis on protein–protein associations and self-assembly. He has published more than 200 peer reviewed articles.

Table of Contents

Chapter 1 Size and Shape of Protein Molecules

Chapter 2 Basic thermodynamics of reversible association 

Chapter 3 The nature of the protein-protein bond, à la Chothia and Janin 

Chapter 4 The structure of an antibody bound to its protein ligand – lock and key vs induced fit 

Chapter 5 The complex of growth hormone with its receptor – one protein interface binds two partners 

Chapter 6 The hot spot in protein-protein interfaces

Chapter 7 Cooperativity in protein-protein association and efficiency of bonds

Chapter 8 Kinetics of protein-protein association and dissociation

Chapter 9 Techniques for measuring protein-protein association – use and abuse of ELISA 

Chapter 10 Fibronectin, the FNIII domain, and artificial antibodies 

Chapter 11 Association of intrinsically disordered proteins – flexible binding partners  


Hardback ISBN: 9780750324106

Ebook ISBN: 9780750324120

DOI: 10.1088/2053-2563/ab19ba

Publisher: Institute of Physics Publishing

Series: Biophysical Society-IOP Series


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