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Practical Radiobiology for Proton Therapy Planning

Dr Bleddyn Jones


Practical Radiobiology for Proton Therapy Planning covers the principles, advantages and potential pitfalls that occur in proton therapy, especially its radiobiological modelling applications. This book is intended to educate, inform and to stimulate further research questions. Additionally, it will help proton therapy centres when designing new treatments or when unintended errors or delays occur. The clear descriptions of useful equations for high LET particle beam applications, worked examples of many important clinical situations, and discussion of how proton therapy may be optimized are all important features of the text. This important book blends the relevant physics, biology and medical aspects of this multidisciplinary subject.

About Editors

Bleddyn Jones is Professor of Clinical Radiation Biology at the new Gray Institute for Radiation Oncology and Biology at the University of Oxford, as well as Honorary Consultant in Clinical Oncology, Oxford Radcliffe Hospitals NHS Trust. Over the past 20 years he has been involved with selection and referral of patients abroad for particle therapy. Present research interests include development of new accelerator technology, better prediction of the biological effects of different qualities of radiation and the role of fractionation in particle beam therapy. He is Deputy Director of the Oxford Master of Science course in Radiation Biology and Co-Director of the new Particle Therapy Cancer Research Institute. 

Table of Contents


1. Particle physics for biological interactions

2. The essential radiobiology background

3. Some important medical and surgical considerations, including clinical trials

4. Treatment planning and further medical perspectives

5. Historical development of radiotherapy including what was learned from fast neutrons

6. Fractionation

7. The case for using a variable proton RBE

8. A general RBE simple efficiency model for protons and light ions

9.  Inclusion of the energy-efficiency LET and RBE model in proton therapy

10. Compensating for elapsed time: unintended treatment interruptions & re-treatments

11. Errors of Bragg Peak Positioning and their radiobiological correction

12. Additional considerations and conclusions


Hardback ISBN: 9780750313391

Ebook ISBN: 9780750313384

DOI: 10.1088/978-0-7503-1338-4

Publisher: Institute of Physics Publishing

Series: IPEM-IOP Series in Physics and Engineering in Medicine and Biology


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