Physics of Cancer: Second edition, volume 2
- Cellular and microenvironmental effects
- Claudia Tanja Mierke
- October 2018
Description
In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The underlying physical principles of these oncological processes are a major constituent of the research field highlighted in Physics of Cancer.This completely revised second edition of is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.
About Editors
Claudia Tanja Mierke has a background in biology and molecular oncology and is head of the biological physics division at the University of Leipzig where she regularly teaches molecular and cell biology, biophysics and soft matter physics to physicists. She is concerned with various research areas developing our understanding of the physical aspects of cancer.Table of Contents
About the author
Introduction
1 Initiation of a neoplasm or tumor
2 Inflammation and cancer
3 Cellular stiffness and deformability
4 Cell–cell and cell–matrix adhesion strength, local cell stiffness and forces
5 Cell surface tension, the mobility of cell surface receptors and their location in specific regions
6 Cytoskeletal remodeling dynamics
7 Actin filamen during matrix invasion
8 Intermediate filaments during matrix invasion
9 Microtubules during migration and matrix invasion
10 Nuclear deformability during migration and matrix invasion
11 The mechanical and structural properties of the microenvironment
12 The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion
13 The active role of the tumor stroma in regulating cell invasion
14 The role of endothelial cell-cell adhesions
15 The mechanical properties of endothelial cells altered by aggressive cancer cells
16 The role of macrophages during cancer cell transendothelial migration
Bibliographic
Hardback ISBN: 9780750321143
Ebook ISBN: 9780750321174
DOI: 10.1088/978-0-7503-2117-4
Publisher: Institute of Physics Publishing
Series: Biophysical Society-IOP Series