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Physics of Cancer: Second edition, volume 2

Cellular and microenvironmental effects
Claudia Tanja Mierke

Description

In order to increase the healing opportunities of cancer, it is important to impair the dissemination and the spreading of cancer cells from the initial tumor and the formation of metastases in other organs or tissues of the human body. The underlying physical principles of these oncological processes are a major constituent of the research field highlighted in Physics of Cancer.

This completely revised second edition of is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.

About Editors

Claudia Tanja Mierke has a background in biology and molecular oncology and is head of the biological physics division at the University of Leipzig where she regularly teaches molecular and cell biology, biophysics and soft matter physics to physicists. She is concerned with various research areas developing our understanding of the physical aspects of cancer.

Table of Contents

Preface

About the author

Introduction

1 Initiation of a neoplasm or tumor                                                                          

2 Inflammation and cancer                                                                                        

3 Cellular stiffness and deformability                                              

4 Cell–cell and cell–matrix adhesion strength, local cell stiffness and forces

5 Cell surface tension, the mobility of cell surface receptors and their location in specific regions

6 Cytoskeletal remodeling dynamics                                                            

7 Actin filamen during matrix invasion

8 Intermediate filaments during matrix invasion                                                   

9 Microtubules during migration and matrix invasion                             

10 Nuclear deformability during migration and matrix invasion

11 The mechanical and structural properties of the microenvironment

12 The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion

13 The active role of the tumor stroma in regulating cell invasion

14 The role of endothelial cell-cell adhesions                                                        

15 The mechanical properties of endothelial cells altered by aggressive cancer cells

16 The role of macrophages during cancer cell transendothelial migration

Bibliographic

Hardback ISBN: 9780750321143

Ebook ISBN: 9780750321174

DOI: 10.1088/978-0-7503-2117-4

Publisher: Institute of Physics Publishing

Series: Biophysical Society-IOP Series

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