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Physics of Cancer

Claudia Tanja Mierke


Physics of Cancer focuses on the mechanical properties of cancer cells and their role in cancer disease and metastasis. It discusses the role of the mechanical properties of interacting cells and the connective tissue microenvironment and describes the role of an inflammation during cancer disease. This outstanding book is the first to describe cancer disease from a biophysical point of view without being incomplete in describing the biological site of cancer. Originating in part from the author's own courses on tumor biology and cellular biophysics, this book is suitable for both students and researchers in this dynamic interdisciplinary field, be they from a physical, biological or medical sciences background.

About Editors

Claudia Tanja Mierke has a background in biology and molecular oncology and is Head of the Biological Physics Division at the University of Leipzig where she regularly teaches molecular and cell biology, biophysics and soft matter physics to physicists. She is concerned with various research areas developing our understanding of the physical aspects of cancer.

Table of Contents

About the author
Part 1 Introduction to tumor biology from a biophysical point of view
1 Initiation of a neoplasm or tumor
2 Inflammation and cancer
Part 2 The role of the mechanical properties of cancer cells in cellular invasion
3 Cellular stiffness and deformability
4 Cell–cell and cell–matrix adhesion strength, local cell stiffness and forces
5 Cytoskeletal remodeling dynamics
6 Intermediate filaments and nuclear deformability during matrix invasion
7 Cell surface tension, the mobility of cell surface receptors and their location in specific regions
Part 3 The impact of the tumor microenvironment on cellular
8 The mechanical and structural properties of the microenvironment
9 The impact of cells and substances within the extracellular matrix tissue on mechanical properties and cell invasion
Part 4 The impact of the mechanical and biochemical interaction of cancer cells with other cells in transendothelial migration
10 The role of endothelial cell-cell adhesions 10-1
11 The mechanical properties of endothelial cells altered by aggressive cancer cells
12 The role of macrophages during cancer cell transendothelial migration


Hardback ISBN: 9780750311359

Ebook ISBN: 9780750311342

DOI: 10.1088/978-0-7503-1134-2

Publisher: Institute of Physics Publishing


Claudia Tanja Mierke's Physics of Cancer provides a wide-ranging introduction to the application of modern biophysical concepts to cancer research. The book's first section provides a broad overview that readers unfamiliar with cancer science or biophysics could appreciate. Overall, the content in Physics of Cancer is up-to-date, interesting, and highly relevant.

Dennis E. Discher 2016 Physics Today, American Institute of Physics

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