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Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles

Application to drug delivery system
Huilin Ye, Zhiqiang Shen, Ying Li

Description

Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. Current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of the multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow.

About Editors

Huilin Ye is a PhD candidate in mechanical engineering at the University of Connecticut. His research interests are mainly concerned with developing high-fidelity computational methods in biosystems, especially for blood flow. Yeʼs works have been recognized by fellowships and awards including a Generic Electric Fellowship for Innovation and the Best Paper Award from the FDTC student paper competition in EMI (2018) from ASCE.

Zhiqiang Shen is a PhD candidate in mechanical engineering at the University of Connecticut. His current research interests focus on multi-scale modelling of nanoparticle-mediated drug delivery and polymeric materials. Shenʼs works have been recognized by fellowships and awards including a Generic Electric Fellowship for Innovation (2017) and an ASME SPC Award (2019).

Ying Li joined the University of Connecticut in 2015 as an assistant professor in the Department of Mechanical Engineering. He received his PhD in 2015 from Northwestern University. Li's achievements and awards include the Best Paper Award from the ASME Global Congress on NanoEngineering for Medicine and Biology, an International Institute for Nanotechnology Outstanding Researcher Award, a Chinese Government Award for Outstanding Students Abroad, and a Ryan Fellowship.

Table of Contents

1 Background

1.1 Blood flow in human vasculature

1.2 Vascular targeting and margination of particles in blood flow

1.3 Adhesion of particles on endothelium wall

I Numerical Method

2 Numerical methods: fluid structure interaction and adhesive dynamics

2.1 Fluid-structure interaction

2.1.1 Plasma dynamics: Lattice Boltzmann method

2.1.2 Coarse-grained model for blood cells and particles

2.1.3 Immersed boundary method

2.2 Adhesive dynamics

2.3 Validation of Numerical Method

2.3.1 Validation of RBC Model

2.3.2 Validation of RBC suspension

II Applications

3 Anomalous vascular dynamics of nanoworms within blood flow

3.1 Motivation

3.2 Experimental and computational results

3.2.1 Experiment

3.2.2 Computational results

4 Adhesion behavior of single cell on endothelial wall

4.1 Introduction

4.2 Computational model

4.3 Results and Discussion

4.3.1 Four Types of Motion and Demargination

4.3.2 Effect of Particle Stiffness on Formation of Bonds and Adhesive Force

4.3.3 Phase Diagram and Scaling Relationship

5 Localization of soft particle: margination and adhesion

5.1 Introduction

5.2 Physical Problem and Computational Method

5.2.1 Physical problem

5.3 Results and Discussion

5.3.1 Margination of elastic MPs without adhesion

5.3.2 Adhesion effect on localization of elastic MPs at wall

5.3.3 Adhesion behavior of elastic MPs

5.3.4 Mechanism of localization of elastic MPs under adhesion

6 Shape dependent transport of micro-particles in blood flow: from margination to adhesion

6.1 Introduction

6.2 Computational model setup

6.3 Results and Discussion

6.3.1 Margination of MPs without adhesion

6.3.2 Margination of MPs with adhesion

6.3.3 Mechanism of adhesion effect

A Coarse-grained potential for RBC

Bibliographic

Paperback ISBN: 9780750330190

Ebook ISBN: 9781643277912

DOI: 10.1088/2053-2571/ab4124

Publisher: Morgan & Claypool Publishers

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