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Biophysical and Chemical Properties of Collagen: Biomedical Applications

Professor John A.M. Ramshaw, Dr Veronica Glattauer


Collagen has proved to be a safe and effective biomedical material. Clinicians have used collagen-based devices in a wide range of applications with successful patient outcomes. This book gives an understanding of how present devices work, how they could be improved, and the development of new devices where a knowledge of collagen structure, chemistry and biology is required. The purification of collagen materials and the fabrication of a range of collagen products and their applications are covered within. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students.

About Editors

John A M Ramshaw is a chemist who studied at Van Mildert College, Durham University, UK, where he was awarded BSc, PhD and DSc degrees. He recently retired as a chief research scientist at CSIRO and is now at The University of Melbourne. He has extensive experience of collagen and biomedical materials, through research leading to papers and patents, consulting and innovation.

Veronica Glattauer graduated from La Trobe University in Melbourne, Australia, with a BSc in chemistry and biochemistry. She was later awarded a PGDip in computer science from Monash University. She has extensive scientific knowledge in the area of biomaterial science and engineering, extracellular matrix biology (principally collagen), protein chemistry, and cell biology.

Table of Contents


I Introduction

1 Introduction

II The Structure and Biochemistry of Collagen

2 The structure of collagen

3 Biosynthesis and biodegradation of collagen

4 Collagen Assemblies

5 Tissue Arrangement

6 Collagen stability

7 Interactions

III  The Production of Collagen-based Biomaterials

8 Production of tissue derived collagens

9 Production of recombinant collagens

10 Evaluation of the Quality of Collagen Preparations

11 Fabrication of biomedical products

12 Chemical Modifications

IV  Applications of collagen in medical products

13 Applications for intact tissue collagen

14 Applications for purified collagen

15 Applications of biosynthetic materials

16 Collagen applications in tissue engineering and regenerative medicine

17 Coating of biomedical materials with collagen

18 Composites of collagen with other materials

V Conclusions

19 Concluding remarks


Hardback ISBN: 9780750320948

Ebook ISBN: 9780750320962

DOI: 10.1088/2053-2563/ab2c6b

Publisher: Institute of Physics Publishing

Series: Biophysical Society-IOP Series


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