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Single-particle CryoEM of Biological Macromolecules

Robert M Glaeser, Eva Nogales, Wah Chiu


This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book, provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results.

About Editors

Table of Contents

1. Introduction and overview
2. Sample preparation
3. Data collection
4. Data processing
5. Map validation
6. Model building and validation


Hardback ISBN: 9780750330374

Ebook ISBN: 9780750330398

Publisher: Institute of Physics Publishing

Series: Biophysical Society-IOP Series


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