Advancement in the field of nanotechnology has revolutionized the field of medicines and pharmaceuticals in the 20th century. The proper use of nanomaterials in medical applications requires a proper understanding of these compounds. This correct understanding, beyond the physical and chemical properties, must also have the correct logic of use. In other words, the strategic use of nanomaterials with applicable perspective can also help to advance research, but if we go forward with the current research perspective that leads to the expansion of inapplicable researches, the intrinsic importance of using these nanomaterials is eliminated.
This book, considering the importance of nanomaterials and their application in medicine, as well as the significant growth of biomaterials in research fields, introduces the variables law (Rabiee's theory) for the implementation of this research and the establishment of a proper strategy. It should be noted that in addition to observing biocompatibility tests for a biomaterial based on existing protocols and standards, the Applicable Compatibility (AC) parameter is also required in accordance with Rabiee's theory. This book is written in accordance with Rabiee's theory and the contents of this book should be evaluated from this perspective.
Navid Rabiee graduated with an MSc in Inorganic Chemistry from Shahid Beheshti University, in 2018. He also worked on drug delivery systems based on biocompatible and biodegradable polymers associated with different types of the sensitizers, especially porphyrins, under the supervision of Professor Mohammad Rabiee at Amirkabir University of Technology, Tehran, Iran.
Mohammad Rabiee, PhD, is an associated professor of the Biomedical Engineering Department of Amirkabir University of Technology, Tehran, Iran. His current research interests include smart drug delivery systems, tissue engineering and biological sensors. He has published more than 100 ISI papers and also more than 70 international conference papers. He has been teaching and doing research for more than 26 years at Amirkabir University of Technology, Tehran, Iran.
Reza Salarian, PhD, is an assistant professor of Biomedical Engineering of Maziar University, Noor, Iran. He also worked as a researcher at Amirkabir University of Technology, Tehran, Iran.
Ghazal Rabiee is an MSc student in Inorganic Chemistry with a major in Inorganic Catalysis at Shahid Beheshti University, Tehran, Iran. Her work has resulted in the publication of approximately four peer-reviewed journal articles and one book.
Table of Contents
1.1. Metallic nano particles:
1.4. Nanomaterials classifications
1.5. Fabrication methods
2.1. Polymers as bioactive materials
2.1.1. Non-biodegradable polymers
2.1.2. Biodegradable polymers
2.2. Composites as bioactive materials
2.3. Biodegradable metals as bioactive materials
2.5. Mechanical behavior of bioactive glasses
Bio-Inspired approaches: carbon-based nanomaterials
3. Carbon-based nanomaterials as a therapeutic platform
3.1. Cargo attachment
3.2. Cell targeting
3.3. Cargo delivery
3.4. Non targeted cargo delivery
3.6. Future biomedical challenges
Nanomaterials and Biomedical applications
4. Nanomaterials and tissue engineering
4.1. Remodeling induces by myocardial infarction
4.2. Remodeling induces by hypertension
4.3. Recent Pharma approaches
5.1. Hydrolase-responsive nanomaterials
5.1.1 Protease-responsive nanomaterials
5.1.2 Trypsin–responsive nanomaterials
5.1.3. Elastase-responsive nanomaterials
5.1.4. Lipase responsive nanomaterials
5.1.5. Glycosidase- responsive nanostructures
220.127.116.11. Hyaluronidase-responsive nanostructures
18.104.22.168 Chitosanase-responsive nanomaterials
22.214.171.124 Amylase-responsive nanomaterials
126.96.36.199. Cellulase-responsive nanomaterials
5.1.6 Other hydrolase-responsive nanomaterials
5.2. Oxidoreductase-responsive drug delivery systems
5.2.1. Glucose oxidase
5.2.4 Glutathione reductase