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Intensity Modulated Radiation Therapy

A Clinical Overview
Indra J. Das, Nicholas J. Sanfilippo, Antonella Fogliata, Luca Cozzi


Intensity modulated radiation therapy (IMRT) has become standard of care for most cancer sites that are managed by radiation therapy. This book documents the evolution of this technology over 35 years to the current level of volumetric arc modulated therapy (VMAT). It covers every aspect of this radiation treatment technology, including the fundamentals of IMRT/VMAT, basic principles and advanced processes for implementation. The physics of IMRT is followed by the clinical application in major disease sites such as central nervous system, head and neck, breast, lung, prostate and cervix. It also provides updated references on each component of IMRT/VMAT. This book is written by leading experts in the field with extensive clinical experience in the practice and implementation of this technology.

Key Features
  • Provides comprehensive coverage of IMRT for radiation therapy students, dosimetrists, physicists, medical residents and radiation professionals
  • Includes up-to-date descriptions of current instrumentation and practises
  • Diagrams and images are included throughout to illustrate fundamental concepts and aid understanding
  • Provides extensive references for further reading

About Editors

Indra J Das is currently Vice Chair, Professor and Director of medical physics at Northwestern University Feinberg School of Medicine in Chicago. He is serving or has served on several journal editorial boards including International Journal of Radiation Oncology Biology Physics, Medical Physics, British Journal of Radiology, and Journal of Radiation Research.

Nicholas J Sanfilippo is a radiation oncologist with special interest in treatment of head and neck, thoracic, cutaneous, and genitourinary malignancies. He joined Weill Cornell Medicine in 2018 as Vice Chairman of the Department of Radiation Oncology, Residency Program Director, and Director of Quality Assurance.

Antonella Fogliata is a research scientist at the Humanitas Research Hospital in Milan-Rozzano. She teaches many courses covering radiotherapy advanced technologies for medical physicists and clinicians. She serves as Associate Editor on a number of journals, including Physica Medica.

Luca Cozzi was the head of the physics unit at the Oncology Institute of Southern Switzerland and a research scientist at the Humanitas Research Hospital. He has acted as a Privat Docent at the University of Lausanne, Adjunct Professor at the Humanitas University, and president of the Swiss Society of Radiobiology and Medical Physics.

Table of Contents

Author biographies
Chapter 1 - Introduction
Chapter 2 - Beam modulation
Chapter 3 - Definitions and terminology
Chapter 4 - IMRT devices
Chapter 5 - IMRT, IMAT and VMAT
Chapter 6 - Intensity modulated planning process
Chapter 7 - Contouring
Chapter 8 - Treatment planning
Chapter 9 - Optimization
Chapter 10 - Dose calculation
Chapter 11 - Plan variability
Chapter 12 - Quality assurance and verification
Chapter 13 - IMRT dose prescription and recording
Chapter 14 - Tumors of the central nervous system
Chapter 15 - Head and neck cancer
Chapter 16 - Lung cancer
Chapter 17 - Breast cancer
Chapter 18 - Prostate cancer
Chapter 19 - Cervical cancer
Chapter 20 - Summary and outlook


Hardback ISBN: 9780750313360

Ebook ISBN: 9780750313353

DOI: 10.1088/978-0-7503-1335-3

Publisher: Institute of Physics Publishing

Series: IPEM-IOP Series in Physics and Engineering in Medicine and Biology


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