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Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 2

Preclinical and multimodality imaging
Andreas Walter, Julia Mannheim, Carmel J Caruana


The relentless pace of innovation in biomedical imaging has provided modern researchers with an unprecedented number of techniques and tools to choose from. While the development of new bioimaging techniques is vital for ongoing progress in the life sciences, it has made it harder than ever for researchers to keep pace. Imaging Modalities for Biological and Preclinical Research is designed to provide a comprehensive overview of currently available biological and preclinical imaging methods, including their benefits and limitations. Experts in the field guide the reader through both the physical principles and biomedical applications of each imaging modality, including description of typical setups and sample preparation.

Volume 2 begins by covering in vivo imaging methods, including intravital microscopy, ultrasound, MRI, CT and PET. With individual techniques covered across the two volumes, discussion then turns to correlative multimodal imaging and how it can be used to obtain more information about a specimen. The volume concludes with a look ahead to emerging technologies and the future of imaging in biological and preclinical research.

Key Features
  • Provides an overview of fast-evolving imaging technologies.
  • Bridges biological and preclinical imaging.
  • Written by imaging specialists with extensive expertise in their respective fields.

About Editors

Table of Contents


Part II: In vivo imaging

II.1 - Intravital microscopy

II.2 - Optical coherence tomography (OCT)

II.3 - Photoacoustic imaging

II.4 - Optical imaging
II.4.a Fluorescence
II.4.b Bioluminescence
II.4.c Cerenkov luminescence imaging

II.5 - Confocal and multiphoton endomicroscopy

II.6 - Preclinical in vivo ultrasound imaging

II.7 - Magnetic resonance imaging
II.7.a Nuclear magnetic resonance spectroscopy and imaging
II.7.b Functional magnetic resonance imaging
II.7.c Hyperpolarized 13C magnetic resonance spectroscopic imaging

II.8 - Magnetic particle imaging

II.9 - Computed tomography in biomedicine

II.10 - Positron emission tomography (PET)

II.11 - Single photon emission computed tomography (SPECT)

Part III: Correlative multimodal imaging and image data fusion

III.1 - Biological correlative imaging
III.1.a Correlative light electron microscopy (CLEM)
III.1.b Correlative atomic force microscopy

III.2 - (Pre)clinical hybrid imaging
III.2.a PET/CT imaging
III.2.c Positron emission tomography/magnetic resonance imaging
III.2.d Combined fluorescence molecular tomography and computed tomography (FMT/CT) to track and quantify systemically applied NIR-dye labeled nucleic acid
III.2.e Hybrid PET-CT-ultrasound imaging

III.3 - Correlative multimodality imaging across scales

III.4 - Multimodal image processing
III.4.a Introduction—computer-assisted analysis of multimodality image data
III.4.b Multimodality image registration
III.4.c Learning-based approaches for multimodality imaging
III.4.d Multimodality image segmentation
III.4.e Visualization for correlative multimodality imaging
III.4.f Data compression algorithms for biomedical images
III.4.g Perspectives and conclusion—computer-assisted analysis of multimodality image data

Part IV: Future of Imaging in Biological and Preclinical Research
IV.1 Emerging technologies and outlook


Hardback ISBN: 9780750337458

Ebook ISBN: 9780750337472

Publisher: Institute of Physics Publishing

Series: IPEM-IOP Series in Physics and Engineering in Medicine and Biology


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